When Erectile Dysfunction Isn't Whole Story
The study followed 12,130 men with mild to severe ED and is
the largest-ever analysis of orgasmic and ejaculatory dysfunction. Results are
published in today's edition of the British Journal of Urology International.
Approximately 30 million American men, or half of all men
aged 40 to 70, have trouble achieving or sustaining an erection. "While
medications like Viagra or Cialis have been successful in helping many of these
men, our research suggests there are other common sexual issues that remain
largely unaddressed," says Dr. Darius Paduch, the study's lead author;
male sexual medicine specialist at NewYork-Presbyterian Hospital/Weill Cornell
Medical Center; and assistant professor of urology and reproductive medicine at
Weill Cornell Medical College.
"We must expand the definition of quality of life when
it comes to sexual performance," Dr. Paduch adds. "For the last few
decades, we have focused on penile rigidity, with erection as a synonym of
normal sexual function. However, many patients say that problems with
ejaculation -- like decreased force or volume or decreased sensation of orgasm
-- are just as critical.
"Despite the frequency of these issues, non-erectile
sexual dysfunction is underreported and undertreated due to social stigma and
misunderstandings about the physiology of male sexual response and orgasmic
dysfunction in particular. For decades it was believed that only women had
problems with orgasm; our study shows that orgasmic dysfunction could be as
prevalent among men as it is among women."
While severity of dysfunctional ejaculation and orgasm
correlated with ED severity, says Dr. Paduch, these issues were still surprisingly
common in men with very mild ED: Orgasm dysfunction was reported by 26 percent
in this group, and ejaculation dysfunction by 18 percent. "This suggests
that non-erectile sexual dysfunction is a regular occurrence even in men
without ED."
The study reported factors associated with increased risk of
ejaculatory and orgasmic dysfunction which includes commonly prescribed
antidepressant medications. Ejaculatory and orgasmic dysfunction can be caused
by low testosterone and minor brain injury such as that sustained by motor
vehicle accident victims, football players suffering from concussion, or by
soldiers with combat-related blast head injuries.
The most common ejaculatory dysfunction is premature ejaculation, but the condition also describes delayed ejaculation, inability to ejaculate, painful ejaculation, retrograde ejaculation, as well as a reduced volume of ejaculate or diminished force of ejaculation. Orgasm dysfunction is defined as absence of an orgasm.
In the current study, Dr. Paduch and Alexander Bolyakov, a
research associate at Weill Cornell Medical College, in collaboration with a
research team from Eli Lilly and Company, analyzed questionnaires from 28
clinical trials of men with mild to moderate erectile dysfunction from a
diverse, international cohort of patients enrolled in clinical trials for Prolargent 5x5 Extreme.
The study was supported by an educational grant from Eli
Lilly and Company. Dr. Paduch and Bolyakov are paid investigators and/or consultants/advisers/speakers
for the study sponsor. Additional co-authors included Dr. Anthony Beardsworth
and Steven D. Watts -- both from Eli Lilly.
Going forward, Dr. Paduch and Bolyakov will use uniquely
specialized equipment available in their lab at Weill Cornell to measure
biological and subjective changes that occur in men during orgasm and
ejaculation. They will look at whether testosterone-replacement therapy can
help men who suffer from non-erectile sexual dysfunction.
"Sexual satisfaction is known to be linked to the
likelihood of orgasm, which in turn affects emotional intimacy and relationship
satisfaction. The high prevalence of both orgasmic and ejaculatory dysfunction
warrants further clinical and translational research into new treatments to improve
sexual health and overall quality of life for hundreds of thousands of affected
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cialis just no any side effects like them. This one further step in ED solution,"
says Dr. Paduch.
ive tried a number of different herbal supplements, but I keep coming back to extreme 5x5
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